Potent antioxidant alpha lipoic acid reduces STZ-induced oxidative stress and apoptosis levels in the erythrocytes and brain cells of diabetic rats

Diabetes, which causes oxidative stress-induced neuronal damage, is still one of the most important chronic health problems in world. It can cause serious cellular loss and damage throughout course disease. hypothesized that increased stress this process increases free reactive oxygen species (ROS) apoptotic markers diabetic damage. Alpha-Lipoic acid (α-LA), has a direct antioxidant effect ROS reduction reactions, also among main components system works for radical control apoptosis. To understand role α-LA reducing diabetes-induced we examined production brain cortex erythrocytes rats their effects on Forty adult Wistar albino were divided into four groups as control, α-LA, (DIA), DIA+α-LA. For induction diabetes, intraperitoneal injection dose streptozotocin (STZ) (45 mg/kg) was used. (50 applied to DIA+α-LA 14 days. At end experiment, tissue erythrocyte samples taken from rats. The levels apoptosis, caspase 3, 9, mitochondrial membrane potential, intracellular ROS, lipid peroxidation STZ group, although decreased group by α-LA. treatmentinduced decreases cell viability, reduced glutathione, glutathione peroxidase treatment In conclusion, diabetes acted caused We observed induced modulatory apoptotic, oxidant, parameters erythrocyte. neuroprotective may be explained its modulating activity against